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DB2313
First-in-class potent small-molecule inhibitor of PU.1, disrupting the interaction of PU.1 with target gene promoters and leading to downregulation of canonical PU.1 transcriptional targets
DB818
Novel HOXA9 Transcription Factor Inhibitor, targeting the DNA minor groove, bindjng rapidly and specifically to parasite kinetoplast DNA (k-DNA)
DBET1
Novel competitive antagonist of BET bromodomains to hijack the Cereblon E3 ubiquitin ligase complex
DBET6
Novel degrader of BET bromodomain proteins, prompting a collapse of global elongation that phenocopies CDK9 inhibition
DBIBB
Novel LPA2 receptor-specific nonlipid agonist, mitigating cell and tissue injury in vitro and in vivo, protecting cells from radiation injury and enhancing DNA repair via LPA2
DCAI
Inhibitor of nuleotide exchange and nucleotide release, binding to the pocket adjacent to the Ras-SOS interface