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LOXO-195 (Selitrectinib)
Next-generation, selective TRK inhibitor, overcoming the resistance for larotrectinib (LOXO-101) or multikinase inhibitors with anti-TRK activity
Loxoprofen
Non-selective cyclooxygenase inhibitor, as a non-steroidal anti-inflammatory drug (NSAID)
LP-533401 HCl
Novel inhibitor of tryptophan hydroxylase-1 (Tph-1), the initial enzyme in gut-derived serotonin (GDS) biosynthesis.
LP99
Novel BRD7/9 specific inhibitor, binding to BRD9 with a higher potency (Kd=99nM) than to BRD7 (Kd=909nM, ITC), with no off-target selectivity in vitro
LRE1 (RU-0204277)
Novel specific and allosteric inhibitor of soluble adenylyl cyclase (sAC), binding to the bicarbonate activator binding site and inhibiting sAC via a unique allosteric mechanism, preventing sAC-dependent processes in cellular and physiological syst..
LT175
Novel PPARα/γ ligand with potent insulin sensitizing effects and reduced adipogenic properties
Lu AF32615 (TCN-238)
Selective and brain-penetrant positive allosteric modulators (PAMs) of the mGlu4 receptor