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NCB-0846
The first orally available small-molecule TNIK inhibitor, having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis, also inhibiting FLT3, JAK3, PDGFRa, TRKA, CDK2/CycA2, and HGK
NCGC00244536 (KDM4B-IN-B3)
Novel KDM4 inhibitor, blocking the binding of KDM4B to the PLK1 promoter, suppressing the expression of AR and BMYB-regulated genes
NCGC607
Novel noninhibitory chaperone of glucocerebrosidase, restoring glucocerebrosidase activity and protein levels, and reducing glycolipid storage in both iPSC-derived macrophages and dopaminergic neurons, indicating its potential for treating neuronop..
NCT-502
Novel inhibitor of homo sapiens phosphoglycerate dehydrogenase (PHGDH), reducing the production of glucose-derived serine in cells and suppressing the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors
NCT-503
Novel inhibitor of homo sapiens phosphoglycerate dehydrogenase (PHGDH), reducing the production of glucose-derived serine in cells and suppressing the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors
NDI-091143
Novel potent inhibitor of human ATP-citrate lyase, indirectly disrupting citrate binding via an unexpected mechanism of inhibition