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Sappanone A
Highly selective inhibitor of IMPDH2, demonstrating significant inhibitory effects on neuroinflammation by directly targeting the conserved cysteine residue 140 (Cys140) in the noncatalytic Bateman domain of IMPDH2
Saquinavir Mesylate
Protease inhibitor, binding to the active site of the viral protease and preventing cleavage of viral polyproteins and maturation of the virus, inhibiting both HIV-1 and HIV-2 proteases
SAR245409 ( XL-765, Voxtalisib)
A potent and highly selective pan inhibitor of class I PI3Ks (α/β/γ/δ, IC50=39/110/9/43 nM) with activity against mTOR(IC50=160-910 nM).