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XL147-II
Novel ATP-competitive inhibitor of class I PI3K isoforms, abrogating Akt and S6 phosphorylation in HER2+ cells and also inducing the expression and phosphorylation of HER3 and other RTKs
XL413 (BMS-863233 HCl)
Novel potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor
XS018661
The first-in-class dual inhibitor of ENL (Kd = 754 ± 45 nM) and its paralog AF9 (Kd = 523 ± 53 nM)
Y-320
An inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody.
Y27632 2 HCl
A selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.