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NVP-2

NVP-2
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5 mg $165.00
10 mg $262.50

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Novel selective and ATP-competitive inhibitor of the cyclin-dependent kinase CDK9




































Technical Data
Chemical Formula C27H37ClN6O2
CAS Number 1263373-43-8
Molecular Weight 513.07
Solubility DMSO or EtOH 51.31 mg per 1 mL
IUPAC/Chemical Name 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
Purity 98% by HPLC
Storage 0°C (short term), -20°C (long term), desiccated
InChI Key XWQVQSXLXAXOPJ-QNGMFEMESA-N
Smiles COC[C@H](N[C@H]1CC[C@H](NC2=CC(C3=NC(NCC4(C#N)CCOCC4)=CC=C3)=C(C=N2)Cl)CC1)C
References 1) Olson et al (2018) Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat.Chem.Biol. 14 163 PMID
PubChem ID 66937006