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NSC-144303
Potent inhibitor of general DUB activity leading to acute proteotoxicstress and apoptosis, inducing apoptosis inBcl-2 over-expressing cells
NSC-30176
Inhibitor of human PRMT1, selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9
NSC-33994
A selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 mu; M.
NSC-632839
Inhibitor of the ubiquitin isopeptidases, inducing a rather unique apoptotic pathway including a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa