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Dual inhibitor of receptor tyrosine kinases (RTKs)

Potent inhibitor of Src-family tyrosine kinases

Novel potent and selective mTOR inhibitor, targeting ATP domain of mTOR.

P2 receptor antagonist

Subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors

Novel potent CFTR inhibitor, reducing cyst size in a polycystic kidney disease model

Selective inhibitor of PDE-10

Inhibitor of insulin-like growth factor I receptor signaling and breast cancer cell growth

Gap junction enhancer, restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells

Novel Glutaminyl Cyclase (QCPT) Inhibitor, Improving Cognition in Mouse Models of Alzheimer's Disease

A potent pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR)

An inhibitor of deubiquitylating (DUB) enzymes

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