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Partial mGluR5 partial antagonist

A selective, positive allosteric modulator at the muscarinic M1 acetylcholine receptor

Novel activator of Kir6.2/SUR1

Novel selective Kir4.1 potassium channel pore blocker

Novel positive modulator of smoothened (SMO)

Potent Metabotropic_glutamate_receptor5 PAM modulator

Positive allosteric modulator (PAM) of mGlu4 receptors

Potent, orally bioavailable and CNS penetrant M1 agonist with high selectivity, clean ancillary pharmacology and enantiospecific activity

Positive allosteric modulator at mGlu4 receptors

Novel selective hERG blocker

Novel activator of heme biosynthesis

Novel metabotropic glutamate receptor 5 positive allosteric modulator

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