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Novel mGlu1 positive allosteric modulator (PAM)

Odorant co-receptor (Orco) agonist

Novel agonist of insect olfactory receptors (ORs) acting at a binding site on the Orco subunit

Partial agonist in CXCR3-mediated chemotaxis, bound to CXCR3 in an allosteric fashion with the same efficacy as CXCL11

High-potency ligand that induces recruitment of β-arrestin2 and subsequent internalization of CXCR7

First reported nonpeptidomimetic agonist on the G protein-coupled chemokine receptor CXCR-3

Natural Product

A potent, selective, and orally bioavailable inhibitor of ERK2

A selective inhibitor of Janus kinase 3 (JAK3)

A small-molecule Aurora kinase inhibitor

An orally bioavailable p38 MAP kinase inhibitor developed to treat inflammatory diseases

A novel Caspase-1 inhibitor being investigated for the treatment of epilepsy

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