Selpercatinib (LOXO292)
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Total: $0.00
$0.00
| Unit | Price | Qty |
|---|---|---|
| 5 mg | $92.40 |
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| 10 mg | $147.00 |
|
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Novel potent, highly-selective, and orally-available RET kinase inhibitor
| Technical Data | |
| Chemical Formula | C29H31N7O3 |
| CAS Number | 2152628-33-4 |
| Molecular Weight | 525.61 |
| Solubility | DMSO |
| IUPAC/Chemical Name | 6-(2-hydroxy-2-methylpropoxy)-4-(6-{6-[(6-methoxypyridin- 3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl}pyridin-3- yl)pyrazolo[1,5-a]pyridine-3-carbonitrile |
| Purity | 98% by HPLC |
| Storage | 0°C (short term), -20°C (long term), desiccated |
| InChI Key | XIIOFHFUYBLOLW-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3 |
| Smiles | N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1 |
| References | 1) Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.|| 2) International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 32, No. 4, 2018. |
| Synonym | LOXO-292 |