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GSK114
Novel selective inhibitor for elucidating the biological role of TNNI3K, displaying significant bias (40-fold) for TNNI3K over B-Raf, exceptional broad-spectrum kinase selectivity, and adequate oral exposure to enable its use in cellular and in viv..
GSK126
Potent, highly selective, S-adenosyl-methionine-competitive, inhibitor of EZH2 methyltransferase activity
GSK163090
A potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3, respectively.
GSK1904529A
A potent, selective and orally active inhibitor of the insulin-like growth factor-1 receptor (IGF-1R)
GSK199
Novel selective PAD4 inhibitor with half-maximum inhibitory concentration (IC50) values, in the absence of calcium, of 200 nM