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Triterpenoids

Sesquiterpenoids

Sympatholytic agent, binding to non-adrenergic sites

Alkaloids

Selectively inhibits cFMS kinase (IC50 = 0.03 μM), preventing CSF -induced monocyte growth with an IC50 value of 0.14 μM.

Irreversible PPAR-gamma antagonist

Inhibitor of of the metalloproteinase ADAM17; Inhibitor of the constitutive and the PMA-inducible CX3CL1 cleavage, blocking TACE as well as ADAM10

Potent inhibitor of small conductance calcium-activated potassium (SK) channels, interacting with the channel at the apamin binding site.

A selective, orally active non-steroidal agonist for the liver X receptor (LXR)

Cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase)

a potent and selective peroxisome proliferator-activated receptor (PPAR) β/δ modulator.

cRaf1 kinase inhibitor

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