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Ivosidenib (RG-120 Or AG-120)
First-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein
IWP-3
An inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM
IWP-O1
An inhibitor of Porcupine (Porcn), an acyl (palmitoyl) transferase essential for secretion of Wnt proteins and involved in both embryonic development and tumor progression
IWR-1
A potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response.
Ixazomib Citrate (MLN-9708)
MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome
J014
Novel cGAS-specific inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 100 nM and 60.0 nM for h-cGAS and m-cGAS, respectively)