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JNJ-38877605
An ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.
JNJ-40418677
Novel γ-secretase modulator, inhibiting amyloid plaque formation in a mouse model of Alzheimer's disease
JNJ-56022486
A novel potent and selective negative modulator of AMPA receptors containing TARP-gamma8
JNJ-64619178
Novel potent and selective PRMT5 inhibitor, demonstrating tumor regression in a biomarker-driven human small cell lung cancer
JNJ26854165
Acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.
JNJ303
Novel specific inhibitor of heteromeric Kv7.1/KCNE1 channel complexes in a concentration- and time-dependent manner
JNJ42153605
A potent and selective mGlu2 receptor PAM with an acceptable pharmacokinetic profile in rodent and nonrodent species