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An orally bioavailable and cell permeable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP

Inhibitor of superoxide dismutase (SOD1).

First-in-class dual inhibitor of angiotensin receptor and neprilysin

Highly selective TAM kinase inhibitor, preferentially inhibiting Tyro3, Axl and Mer at low nanomolarity

A Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.

A highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK

Novel activator of glutamate transporter EAAT2 translation

Novel activator of glutamate transporter EAAT2 translation

Potent and selective haspin inhibitor

An potent and reversible EphB3 receptor tyrosine kinase inhibitor

Selective and potent inhibitor of the BMP type I receptor kinases

Novel K02288 analog, inhibiting ALK2 with high degree of selectivity and low cytotoxicity

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